melanoma

Some moles may become larger over time, may develop a mixture of color or may develop uneven borders. These moles are known as dysplastic nevi and are more prone to becoming malignant.

People at high risk for developing melanoma are those who have:

• A family history of or have had a melanoma in the past.
• Unusual moles on the skin, or changing moles.
• Fair skin, light hair and eye color, who sunburn easily or tan with difficulty.
• A history of painful or blistering sunburns as children or teenagers.

Since skin cancers are known to develop more commonly in the area of “BANS”, back, arms, neck and scalp which are the areas most exposed to the sun you might be wondering why I am discussing melanoma since this web site is devoted to foot problems and the feet are generally not exposed as much to the sun as other parts of the body.

It is precisely for that reason that I am discussing melanoma; to make my readers aware that they can occur on the feet and the feet themselves have certain characteristics that may promote the development of melanoma.

The incidence of melanoma is equal between men and women, but lower extremity melanoma is more common in females than males. The majority of cases present between 30-60 years of age.

There are four different categories of melanoma, some of which are more virulent than others. It is not the purpose of this discussion to make you a melanoma expert but rather make you aware of changes in moles that need to be examined by experts.

Specifically, in the foot there are two unique situations that occur. One is any mole that occurs on the bottom of the foot or in between the toes. The reason we worry about moles in these locations is because of the friction that occurs on the skin in these areas, any moles that develop are more prone to undergoing malignant changes due to that excessive friction. So, just because a mole grows in between your toes and you figure it could not have possibly been affected by sun light is no reason not to keep an eye on it or have it inspected by a doctor.

In both those cases, the discoloration should grow forward as the nail grows and eventually will be cut away with the end of the nail. If there is a dark discoloration under the nail that does not seem to be growing forward, (it just stays in the same place) than that discoloration should be considered suspicious. In my office in most cases I can cut away enough nail to visually examine the nail bed and in most cases the discoloration can be removed leaving a healthy nail bed. If I cannot get to the discoloration that way, then I will anesthetize the toe and remove the whole nail, examine the discoloration and if necessary will biopsy the lesion. Again, in the vast majority of cases the discoloration is either from trauma or from fungus.

Regular self exams, all over your body is the best way to become familiar with the many moles and spots you may have on your skin.

In self examination of your moles you need to inspect them for certain characteristics according to their size, color, shape and edges. These are known as the A-B-C-D’s of self examination. They stand for Asymmetry, Border, Color and Diameter.

Below are pictures of various types of moles characterized by the A-B-C-D descriptions. The top mole in each description is normal and the bottom two are malignant.

BORDER meaning that normal moles have even borders, but melanomas frequently have uneven borders.

COLOR of brown, black or tan is normal but once a mole starts having different shades of color it becomes suspicious.

DIAMETER of common moles are usually the size of a pencil eraser head in diameter. Early melanomas tend to be larger than that.

To further complicate the diagnosis of melanoma, there is a variant known as amelanotic melanoma. This is a melanoma with no pigment meaning it does not have a dark discoloration to it. Because of their lack of color these lesions are frequently diagnosed later in their growth meaning they tend to be deeper and more invasive. Fortunately, they do represent less than 5% of all melanomas.

They may be misdiagnosed as eczema, granulation tissue and paronychia (infected ingrown nail).

Typically, on the foot, amelanotic melanoma appears as a non-healing ingrown nail. Many paronychias are associated with a pyogenic granuloma which is a section of inflamed skin adjacent to the ingrown nail. These benign lesions are of a vascular makeup and tend to bleed profusely if cut. In most instances your doctor will cauterize the growth after he removes the offending ingrown nail. If the ingrown nail clears up, but the granuloma persists it should be brought to the attention of your doctor for possible biopsy.

When appearing on the skin, amelanotic melanoma will present as a pink, reddish or even flesh colored. The diagnosis is generally not made until the lesion begins to grow or begins to itch or becomes painful or even begins to bleed. In many instances these lesions will be irritated from chronic shoe or clothing irritation.

As stated before it is important to examine all your moles on your body. Dermatologists recommend yearly examinations.

Interestingly, this year a study out of Rome, Italy found that people with higher serum levels of coenzyme Q (coq 10) has less incidence of melanoma and less metatastasis. Click here for more information on this finding on melanoma. (Journal American Academy of Dermatology, 2006 (ISSN:1097-6787)

As a last comment just because a mole somewhere on your body appears uncharacteristic it does not mean it is malignant but what it does mean is that you should have your doctor look at it immediately. A biopsy is the only way to determine the identity of the mole.